The Role of Heat Shock Proteins in Oxidative Stress Oksidatif Streste Isı Şoku Proteinlerinin Rolü

Abstract

Oxidative stress is at the forefront of these changes that develop during inflammation, which is at the core of diseases. Oxidative stress occurs due to both the excessive release of oxidation products as a result of metabolic activity and a deficiency in the antioxidant system. Oxidative stress, which has recently become a focus of scientific interest, plays a role in the pathogenesis of many diseases. While increased oxidative stress triggers inflammation, a reduction in oxidative stress contributes to the healing process of the disease. Therefore, oxidative stress is beneficial both in understanding diseases and in monitoring various treatment processes. Various biomarkers are used to monitor oxidative stress during inflammation. Heat shock proteins, whose use is gaining momentum in current research, are protein groups that are released during cell injury due to increased intracellular oxidation-induced temperature. Heat shock proteins are responsible for cell development, cycle, metabolism, signaling, proliferation, apoptosis, differentiation, and, in particular, the proper folding of proteins. These proteins are also called stress proteins because they increase under various stress conditions that cause inflammation, such as infection, dehydration, toxicity, starvation, and physical and chemical factors. Heat shock proteins are classified into different groups based on their function and molecular structure. In this research, the structure, types, functions and possible contributions of heat shock proteins to scientific studies were discussed.